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The GIF is led by the Policy Group (PG), the highest-level Committee of the GIF responsible for governing its overall framework and policies, for the overall steering of GIF co-operative efforts and for interactions with third parties. As of 2024, the GIF Policy Group is led by the GIF Chair, with support from 4 Vice Chairs, a Policy Director and a Technical Director.

Recognizing that core topics such as safety, economics, and non-proliferation, along with the challenges to be addressed for the deployment of Generation IV Nuclear Energy Systems, are shared across all six Gen IV Systems, GIF has established cross-cutting Methodology Working Groups (WG). These WGs report to the GIF Experts Groups (EG), solicit inputs, provide support to System Steering Committees, and receive backing from the GIF Technical Secretariat (TS).

Currently, GIF maintains six WGs.

The GIF Economic Modelling Working Group (EMWG) provides a platform and methodology for the assessment of Generation IV (Gen-IV) systems against economic-related goals. It was formed in 2003. 

The EMWG supports the Generation IV goals related to improved economics: 

"Generation IV nuclear energy systems will have a clear life-cycle cost advantage over other energy sources and a level of financial risk comparable to other energy projects."